|
KMID : 0604520170430020103
|
|
Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 2 p.103 ~ p.114
|
|
|
Anti-Inflammatory and Anti-allergic Effects of Gnaphalium affine Extract
|
|
Roh Kyung-Baeg
Lee Jung-A
Park Jun-Ho
Jung Kwang-Seon
Jung Eun-Sun
Park Deok-Hoon
|
|
|
Abstract
|
|
|
|
Gnaphalium affine D. DON (GA) has been used as a vegetable as well as a folk medicine in East Asia. The antioxidant and anti-complementary activity of GA extract (GAE) has also been reported. However, little is known about its anti-inflammatory and anti-allergic effect and mechanism of action. In this study, we evaluated the inhibitory effects of GAE on the production of inflammatory mediators such as NO, PGE2, TLR4, eotaxin-1 and histamine. Our results suggest that GAE inhibits the production of NO and PGE2 by inhibiting transcriptional activation via the involvement of iNOS and COX-2. The LPS-induced expression of Toll-like receptor 4 (TLR4) was also attenuated. In addition, GAE inhibited A23187-induced histamine release from MC/9 mast cells. It also inhibited the production of eotaxin-1 induced by IL-4. Collectively, these results suggest that GAE may have considerable potential as a cosmetic ingredient with anti-inflammatory and anti-allergic properties.
|
|
|
KEYWORD
|
|
|
Gnaphalium affine D. DON , nitric oxide , prostaglandin E2 , eotaxin-1 , histamine ,
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|